Alex bloemendal thesis

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Tetrahydrobiopterin BH4 is a cofactor for neuronal nitric oxide synthase.

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BH4 availability is reduced upon NOS activation, such as during hypoxic conditions, and leads to toxin production. We hypothesize that BH4 levels are depleted in the hypoxic brain and that BH4 replacement therapy mitigates the toxic effects of hypoxia on white matter. Methods and Results Transgenic mice were used to visualize oligodendrocytes Metabolic syndrome is a cause of coronary artery disease and type 2 diabetes mellitus.

Camk2n1 resides in genomic loci for blood pressure, left ventricle mass, and type 2 diabetes mellitus, and in the spontaneously hypertensive rat model of metabolic syndrome, Camk2n1 expression is cis-regulated in left ventricle and fat and positively correlates with adiposity. Therefore, we knocked out Camk2n1 in spontaneously hypertensive rat to investigate its role in metabolic syndrome. Cardiac surgery for the forgotten millions: The way forward. The sustainable development goals provide an important framework for addressing dangerous climate change and achieving wider public health benefits.

Digital literacy linked to engagement and psychological benefits among breast cancer survivors in Internet-based peer support groups. However, this innovation may not benefit survivors equally due to population variance in digital literacy. Telomere length in early childhood is associated with sex and ethnicity. Telomeres are repetitive DNA sequences at the end of chromosomes that function to protect chromosomes from degradation.

Throughout the life course, telomere length decreases with age and is influenced by environmental factors and health conditions.

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This study aimed to determine the relative telomere lengths in a diverse cohort of about four-year-old children in New Zealand. Linear regression was used to investigate the relationship between telomere length, child gender, ethnicity, paternal age and deprivation Using "outbreak science" to strengthen the use of models during epidemics. Protocol: investigating the effectiveness and cost benefit of a lifestyle intervention targeting type 2 diabetes in Australia. A number of interrelated factors increase the risk of the onset of T2DM, however much of the pathogenesis of the disease is associated with lifestyle.

A number of studies have indicated that adopting positive lifestyle changes can successfully prevent or delay the onset of T2DM in a number of different population groups.